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KMID : 0357920000340020113
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Korean Journal of Pathology
2000 Volume.34 No. 2 p.113 ~ p.118
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Expression of Phospholipase C-γ1 and γ2 in Non-Hodgkin’s and Hodgkin’s Lymphoma
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Eom Dae-Woon
Kim Sung-Sook
Woo Yeong-Ju
Suh Jae-Hee
Huh Joo-Ryung
Paik Ae-Ran
Kim Jae-Ho
Ryu Sung-Ho
Suh Pan-Ghil
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Abstract
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Phospholipase C (PLC) plays a role in ligand-mediated signal transduction for cellular activity such as proliferation and differentiation. A recent observation that PLC-γ1 is highly expressed in some kinds of human cancer tissue supports the view that PLC-γ1 may be involved in proliferation and carcinogenesis. PLC-γ2 is known to be involved in B cell differentiation and maturation. However, there have been few studies about the expressions of PLC-γ1 and γ2 in human lymphoid malignancy. In the present study, we examined the contents of PLC-γ1 and γ2 in 10 cases of B cell, 10 cases of T cell non-Hodgkin’s lymphoma and 5 cases of Hodgkin’s lymphoma to find out whether these enzymes play any role in the carcinogenesis by immunohistochemistry and immunoprecipitation. Immunoprecipitation analysis revealed that in contrast to increased expression of PLC-γ2 only in B cell lymphoma, a considerably higher level of PLC-γ1 was detected in both B and T cell lymphoma. Immunohistochemical finding confirmed this observation. PLC-γ1 and PLC-γ2 were expressed in the cytoplasm of most tumor cells. PLC-γ2 was also expressed in mature B cells, while PLC-γ1 was not expressed in reactive non-tumor cells. These results suggest that PLC-γ1 mediated signal transduction implicates a significant role in the carcinogenesis of all types of lymphoid tissue, and PLC-γ2 may play a role in the carcinogenesis of B cell lymphoma as well as B cell differentiation.
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KEYWORD
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PLC-γ1, PLC-γ2, Non-Hodgkin’s lymphoma, Hodgkin’s lymphoma
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